Abstract: The continuous advancement of modern armor protection technology poses increasingly severe challenges to the destructive power of shaped charge warheads. Traditional liner materials, due to their performance limitations, have become a major constraint on improving penetration depth. High-entropy alloys (HEAs), owing to their unique multi-principal element design, exhibit core potential properties such as high strength, high hardness, excellent fracture toughness, and good thermal resistance, making them highly promising candidate materials for new-generation liners. Against this backdrop, systematically investigating the static/dynamic mechanical properties of HEAs and the stability of the jets they form is crucial for developing high-performance shaped charge warheads. This study, through static and dynamic mechanical testing and research on CoCrFeMnNi HEA, determined the dynamic constitutive model and relevant parameters for this material. Numerical simulations of jet formation and target penetration processes for both copper and HEA liners were conducted using LS-DYNA. Compared to copper, the HEA liner formed a more stable and continuous jet. Its unique formation and stretching rupture mechanism ultimately translated into greater penetration depth, confirming the significant advantage of HEA in enhancing destructive efficiency.