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Chinese Journal of High Pressure Physics  > 2010  >  24(4): 293-299 .
LIU Wei, LIU Wei-Lin, LIU Cheng-Mei, YANG Shui-Bing, ZHENG Hui-Juan, LIU Jian-Hua, WANG Jian-Hong. Preparation of Medium-Chain Fatty Acids (MCFA) Nano-Liposome by Means of High Pressure Microfluidization (HPM)[J]. Chinese Journal of High Pressure Physics, 2010, 24(4): 293-299 . doi: 10.11858/gywlxb.2010.04.009
Citation: LIU Wei, LIU Wei-Lin, LIU Cheng-Mei, YANG Shui-Bing, ZHENG Hui-Juan, LIU Jian-Hua, WANG Jian-Hong. Preparation of Medium-Chain Fatty Acids (MCFA) Nano-Liposome by Means of High Pressure Microfluidization (HPM)[J]. Chinese Journal of High Pressure Physics, 2010, 24(4): 293-299 . doi: 10.11858/gywlxb.2010.04.009
shu

Preparation of Medium-Chain Fatty Acids (MCFA) Nano-Liposome by Means of High Pressure Microfluidization (HPM)

doi: 10.11858/gywlxb.2010.04.009

  • State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China

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  • Corresponding author: LIU Cheng-Mei
  • Received Date: 20 Jun 2009
  • Rev Recd Date: 29 Sep 2009
  • Publish Date: 15 Aug 2010
    Abstract
  • Medium-chain fatty acids (MCFA) nano-liposome was prepared and characterized by means of high pressure microfluidization (HPM), sonication and microfiltration, respectively. The average diameter, encapsulated efficiency and stability were investigated after treatment with different pressures and passes number. The results indicated that MCFA liposome prepared by HPM exhibited the smallest average diameter, the largest encapsulated efficiency and the best stability. The smallest average diameter of MCFA liposome could be achieved after a treatment of 6 passes at 120 MPa, with a value of (73.910.2) nm, while the encapsulated efficiency was (52.209.57)%. The largest encapsulated efficiency of (70.6411.25)% and loaded efficiency of (9.420.83)% were obtained when treated 4 passes at 120 MPa, with an average diameter value of (78.921.5) nm. After being treated 4 passes, MCFA liposome exhibited the best stability, with a coefficient value of 0.999 03.695 1.

     

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