高压微射流制备纳米中链脂肪酸脂质体的研究

刘伟 刘玮琳 刘成梅 杨水兵 郑会娟 刘建华 王建红

刘伟, 刘玮琳, 刘成梅, 杨水兵, 郑会娟, 刘建华, 王建红. 高压微射流制备纳米中链脂肪酸脂质体的研究[J]. 高压物理学报, 2010, 24(4): 293-299 . doi: 10.11858/gywlxb.2010.04.009
引用本文: 刘伟, 刘玮琳, 刘成梅, 杨水兵, 郑会娟, 刘建华, 王建红. 高压微射流制备纳米中链脂肪酸脂质体的研究[J]. 高压物理学报, 2010, 24(4): 293-299 . doi: 10.11858/gywlxb.2010.04.009
LIU Wei, LIU Wei-Lin, LIU Cheng-Mei, YANG Shui-Bing, ZHENG Hui-Juan, LIU Jian-Hua, WANG Jian-Hong. Preparation of Medium-Chain Fatty Acids (MCFA) Nano-Liposome by Means of High Pressure Microfluidization (HPM)[J]. Chinese Journal of High Pressure Physics, 2010, 24(4): 293-299 . doi: 10.11858/gywlxb.2010.04.009
Citation: LIU Wei, LIU Wei-Lin, LIU Cheng-Mei, YANG Shui-Bing, ZHENG Hui-Juan, LIU Jian-Hua, WANG Jian-Hong. Preparation of Medium-Chain Fatty Acids (MCFA) Nano-Liposome by Means of High Pressure Microfluidization (HPM)[J]. Chinese Journal of High Pressure Physics, 2010, 24(4): 293-299 . doi: 10.11858/gywlxb.2010.04.009

高压微射流制备纳米中链脂肪酸脂质体的研究

doi: 10.11858/gywlxb.2010.04.009
详细信息
    通讯作者:

    刘成梅

Preparation of Medium-Chain Fatty Acids (MCFA) Nano-Liposome by Means of High Pressure Microfluidization (HPM)

More Information
    Corresponding author: LIU Cheng-Mei
  • 摘要: 以中链脂肪酸(MCFA)为模型材料,比较了高压微射流(HPM)、超声波和微孔过滤3种方法处理后的MCFA脂质体,着重研究了HPM的处理压力和处理次数对脂质体的平均粒度、包封率和稳定性的影响。结果表明:相比超声波和微孔过滤法,HPM处理后的MCFA脂质体的平均粒度最小、包封率最高、稳定性良好;在120 MPa压力条件下处理6次时,MCFA脂质体的平均粒度达到最小,为(73.910.2) nm,包封率为(52.209.57)%;在120 MPa压力条件下处理4次时,包封率和载药量达到最高,分别为(70.6411.25)%和(9.420.83)%,稳定性系数最高,为0.999 03.695 1,平均粒度为(78.921.5) nm。

     

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出版历程
  • 收稿日期:  2009-06-20
  • 修回日期:  2009-09-29
  • 发布日期:  2010-08-15

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